Fig. 1

Involvement of RnKICD in the endogenous homogentisate and heterologous isobutene biosynthesis pathways. RnKICD utilizes α-ketoisocaproate (KIC) to produce isobutene, and ρ-hydroxyphenylpyruvate (HPP) to produce homogentisate. Black arrows indicate native enzymes; solid and dashed red arrows indicate catalysed non-native reactions; blue dotted arrow inicates non-ezymatic decomposition. Red circles indicate structural differences between KIC and HPP